Author's response to reviews Title: Immune correlates of CD4 decline in HIV-infected patients experiencing virologic failure before undergoing treatment interruption Authors:

Author's response to reviews Title: Immune correlates to CD4 decline in HIV-infected patients experiencing virologic failure before undergoing treatment interruption Authors:

Immune correlates of CD4 decline in HIV-infected patients experiencing virologic failure before undergoing treatment interruption

BACKGROUND The advantage of treatment interruptions (TIs) in salvage therapy remains controversial. Regardless, characterizations of the correlates of CD4 count fall during TI are important to identify since patients with virologic failure commonly stop antiretroviral (ARV) therapy. The objective of this study was to determine the predictive value of pre-TI proliferative capacity and cell surfa...

Characteristics and Outcomes of Initial Virologic Suppressors during Analytic Treatment Interruption in a Therapeutic HIV-1 gag Vaccine Trial

BACKGROUND In the placebo-controlled trial ACTG A5197, a trend favoring viral suppression was seen in the HIV-1-infected subjects who received a recombinant Ad5 HIV-1 gag vaccine. OBJECTIVE To identify individuals with initial viral suppression (plasma HIV-1 RNA set point <3.0 log(10) copies/ml) during the analytic treatment interruption (ATI) and evaluate the durability and correlates of vir...

Thymic Output and CD4 T-Cell Reconstitution in HIV-Infected Children on Early and Interrupted Antiretroviral Treatment: Evidence from the Children with HIV Early Antiretroviral Therapy Trial

OBJECTIVES Early treatment of HIV-infected children and adults is important for optimal immune reconstitution. Infants' immune systems are more plastic and dynamic than older children's or adults', and deserve particular attention. This study aimed to understand the response of the HIV-infected infant immune system to early antiretroviral therapy (ART) and planned ART interruption and restart. ...

Treatment interruption in HIV-infected patients with virologic failure may lead to a shift from a drug- resistant to a predominant wild-type plasma viral population

Treatment interruption in HIV-infected patients with virologic failure may lead to a shift from a drugresistant to a predominant wild-type plasma viral population even in individuals with extensive exposure to antiretroviral drugs and multiple virologic failures. Multiple clone sequencing has shown that, after three months of treatment interruption, the proportion of variants harbouring primary...